Well that's a clever idea, I didn't think of
stringing the whole I/O cable out the back.
That's the most flexible thing to do especially if you plan to
make the box fairly sealed.
With my Zero, I still have to go in there to get the SD card.
Bravo.
My plan to finish is to house the RPi externally perhaps in a little box on the back so I can eventually switch in a Next Thing Co CHIP