There are plenty of SBC that use a native 6502. If one took an SBC with a built in breadboard one could swap around the CPU more easily and safer than experimenting on an Apple I !!
You can also use the Ohio Scientific 400 board, which has instructions for using the 6501 in the documentation. We built up an original and tested some 6501s for a friend: https://users.glitchwrks.com/~glitch/2022/09/16/osi-400-build You can also pretty much build a board for the 6501 and test with a 6512. There's one line that's grounded on a 6501 that should be left floating on the 6512, but it doesn't seem to affect operations to leave it grounded. Several folks have built up our reproduction OSI 400 board for testing their 6501. Neil Breeden even built one up to work with a MOS TIM chip, though beware! The OSI manual apparently has +5V and GND reversed on the TIM! Thanks, Jonathan